Senior lecturer, School of Life Sciences at the University of Lincoln.
My research has been directed toward the development of comprehensive proteome-wide chemical profiling strategies to elucidate the mechanisms of leukaemic transformation; that include SILAC, pulse-SILAC and iTRAQ
Research Papers
Graham C,Yang Y, Matta H, Yi H, Suo Y, Chaudhary PM.Kaposi’s sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor induced growth arrest and apoptosis through NF-κB activation. J Virol. (2013) 87, 4. 2242-2252.
Matta H, Gopalakrishnan R, Graham C, Tolani B, Khanna A, Yi H, Suo Y, Chaudhary PM, Kaposi’s Sarcoma Associated Herpesvirus Encoded viral FLICE Inhibitory Protein K13 Activates NF-kappaB Pathway Independent of TRAF6, TAK1 and LUBAC PLoS ONE (2012) 7(5): e36601. i:10.1371/journal.pone.0036601
Jain S, Graham C, Graham R.L, McMullan G, Ternan N.G. (2011) A quantitative proteomic analysis of the heat stress response in Clostridium difficile strain 630. J Prot Res.; 10, 3880-3890.
Dobbin E, Graham C, Freeburn RW, Unwin RD, Griffiths JR, Pierce A, Whetton AD, Wheadon H. (2010) Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways. Stem Cell Res.; 5, 226-43
Dobbin E, Graham C, Corrigan PM, Thomas KG, Freeburn RW, Wheadon H. (2009) Tel/PDGFRbeta induces stem cell differentiation via the Ras/ERK and STAT5 signaling pathways. Exp Hematol.;37, 111-121.
Hoey L, McNulty H, McCann EM, McCracken KJ, Scott JM, Marc BB, Molloy AM, Graham C, Pentieva K.(2009) Laying hens can convert high doses of folic acid added to the feed into natural folates in eggs providing a novel source of food folate. Br J Nutr.; 101, 206-12.
Graham RL, Graham C, Theakston D, McMullan G, Shaw C. (2008) Elucidation of trends within venom components from the snake families Elapidae and Viperidae using gel filtration chromatography. Toxicon.;51 121-9.
Hininger-Favier I, Andriollo-Sanchez M, Meunier N, Bord S, Graham C, Polito A, Maiani G, O’Connor JM, Coudray C, Rousse AM.(2007) Age- and sex-dependent effects of long-term Zinc supplementation on essential trace element status and lipid metabolism in European subjects. The Zenith study. Br J Nutr.; 97 569-78
Graham C, Richter SC, McClean S, O’Kane E, Flatt PR, Shaw C. (2006) Histamine-releasing and antimicrobial peptides from the skin secretions of the Dusky Gopher frog, Rana sevosa. Peptides.;27 1313-9.
Graham RL, Graham C, McClean S, Chen T, O’Rourke M, Hirst D, Theakston D, Shaw C. (2005) Identification and functional analysis of a novel bradykinin inhibitory peptide in the venoms of New World Crotalinae pit vipers. Biochemical and Biophysical Research Communications.; 338: 1587-1592.
Zheng HR, Ojha PC, McClean S, Graham C, Black ND, Hughes JG, Shaw C. (2005) A computational approach for peptidomic analysis in taxonomic study of amphibian species IEEE Transactions on Nanobioscience.; 4, 241-247
Graham C, Irvine AE, McClean S, Richter SC, Flatt PR, Shaw C. (2005) Peptide Tyrosine Arginine, a potent immunomodulatory peptide isolated and structurally characterised from the skin secretions of the dusky gopher frog, Rana sevosa. Peptides.; 26, 737-743.
Invited Reviews (Peer Reviewed)
Graham C, McMullan G,Graham, RL (2011) Proteomics in the Microbial Sciences. Bioengeneered Bugs; 2, 1-14.
Graham RL, Graham C, McMullan G. (2007) Microbial Proteomics: A Mass Spectrometry Primer for Biologists. Microb Cell Fact.; 6, 26. (Highly Accessed)
